21C Museum Hotel Lexington Exterior photo21C Museum Hotel Lexington Exterior photo21C Museum Hotel Lexington Interior photo
Book on our site
Up to 10% cheaper
than Booking.com
Check rooms and rates
From251US$ /night
Check-in
20Apr2026Select date
Check-out
21Apr2026Select date
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

167 West Main Street, Lexington, Kentucky, United States, 40507
-
Steps from the Lexington Convention Center
Great
8.3
8.7
/10
4.4
4.2
/5

Location

21C Museum Hotel Lexington operates in the historic Fayette National Bank Building, an architectural gem designed by McKim, Mead and White. Located in downtown Lexington, the hotel is a short distance from cultural venues and city attractions. Guests enjoy proximity to local dining, shopping, and the extensive Bluegrass region, renowned for its horse farms.

Art Exhibitions

21C Museum Hotel Lexington houses over 7,000 square feet of contemporary art exhibition space. The hotel features rotating exhibitions that highlight global contemporary culture, offering guests a chance to engage with thought-provoking installations. Standout artworks include site-specific pieces such as 'Totally in Love' by Pieke Bergman and 'Spectralline' by SOFTlab.

Dining

Lockbox serves a seasonal menu focusing on locally sourced ingredients and artisanal producers, making the dining experience part of the local culture. Breakfast in bed is available with a daily credit, allowing guests the option to enjoy meals in their rooms or at the restaurant. The hotel also features a unique private dining room located in the restored bank safe.

Accommodations

The hotel offers a variety of room types including 21C Suite, Deluxe King, and Two-bedroom Suite, designed to accommodate diverse guest needs. Each room is adorned with original artwork and outfitted with luxurious Malin + Goetz bath amenities. Guests can expect high ceilings and large historic windows, creating a spacious and inviting atmosphere.

Events and Meetings

21C Museum Hotel Lexington is equipped with an array of event spaces, including a main gallery suitable for both seated groups and receptions. Corporate meetings and private events benefit from advanced audiovisual capabilities and light-filled rooms showcasing contemporary art. The hotel also offers customized catering options highlighting local flavors.

Highlights

Location: downtown Lexington

Art Exhibitions: over 7,000 square feet of exhibition space

Dining: Lockbox restaurant

Accommodations: 21C Suite

Events: main gallery

Private Dining: restored bank safe

Must-do experiences

  • Stroll through the Lexington Farmers Market on Saturdays for fresh local fare.
  • Indulge in a Hot Brown at the famous Lexington Diner for a true local dish.
  • Visit the Mary Todd Lincoln House to discover unique Kentucky history.
  • Explore the urban art at the 21C Museum Hotel that blends art and community.
  • Relax in the scenic parks of the Legacy Trail during a leisurely bike ride.
View all

Select your room type

21C Museum Hotel Lexington offers a variety of rooms including double rooms, family rooms, and suites with breakfast, free cancelations, and special deals
Deluxe Queen Room
2 persons
360 sq. feet 
2 King Size Beds
Shower
Coffee machine
Corner King Room
2 persons
435 sq. feet 
1 King-size bed
Shower
Coffee machine
City Queen Room
2 persons
240 sq. feet 
1 King-size bed
Shower
Coffee machine
Deluxe King Room
2 persons
335 sq. feet 
1 King-size bed
Shower
Coffee machine
Click button to see more rooms
Show all rooms
Show all roomsLess

Price and Room Availability Calendar

Check availability and prices for your dates now!

Facilities

21C Museum Hotel Lexington offers amenities for your comfortable stay and unforgettable experiences
Facilities: Great
8.4/10Review score

General

  • No smoking on site
  • Free Wi-Fi in public areas
  • Safe deposit box
  • 24-hour reception
  • VIP check-in/ -out
  • Pets allowed
  • Rooms/ Facilities for disabled
  • 24-hour security
  • Luggage storage
  • Allergy-free rooms
  • Lift
  • ATM/Cash machine
  • Vending machines
  • Smoke detectors
  • Fire extinguishers
  • Key card access
  • Key access

Sports & Fitness

  • Fitness centre
  • Yoga class

Services

  • Paid shuttle service
  • Room service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Tours/Ticket assistance
  • Welcome drink

Dining

  • In-room breakfast
  • Restaurant
  • Snack bar
  • Bar/ Lounge area
  • Special diet menus

Business

  • Business centre
  • Meeting/ Banquet facilities
  • Fax/Photocopying

Children

  • Children's menu

Room features

  • Air conditioning
  • Heating
  • Soundproofed rooms
  • Sitting area
  • Dressing area
  • Tea and coffee facilities
  • Dining table
  • Ironing facilities

Bathroom

  • Free toiletries

Media

  • Flat-screen TV
  • AM/FM alarm clock
Show more

Dining Onsite

Lockbox offers a delightful exploration of American and local cuisines, expertly accommodating various dietary preferences such as vegetarian, vegan, gluten-free, and dairy-free. Guests are invited to indulge in a culinary experience that marries comfort and creativity within a cozy, inviting atmosphere.
21C Museum Hotel Lexington Restaurant photo
21C Museum Hotel Lexington Restaurant photo
21C Museum Hotel Lexington Restaurant photo

Lockbox

American, Local
Ambiance
Inviting and casual with a focus on local artistry, Lockbox provides a warm environment for relaxation and enjoyment.
Key Offerings
The menu features a range of options catering to different dietary needs, alongside unique offerings that highlight local flavors. The culinary team can also prepare a tailored catering menu for special occasions.
Reservation
Required
Open for breakfast and dinner. Breakfast: Wednesday to Saturday, 7:00 AM - 11:00 AM; Dinner: Wednesday to Thursday, 5:00 PM - 10:00 PM; Friday, 5:00 PM - 10:00 PM; Saturday, 5:00 PM - 11:00 PM; Sunday, 10:00 AM - 2:00 PM and 5:00 PM - 9:00 PM.

21C Museum Hotel Lexington Location

167 West Main Street, Lexington, Kentucky, United States, 40507
Map view
167 West Main Street, Lexington, Kentucky, United States, 40507
Nearby
430 West Vine Street
Rupp Arena
1600 ft
Museum
Hunt-Morgan House
1600 ft
Event hall
Lexington Convention Center
1500 ft
Theatre
Kentucky Theatre
1200 ft
440 W Short St
Explorium
1500 ft
University
University of Kentucky
300 ft
Park
Triangle Park
1200 ft
Church
St Paul the Apostle Catholic Church
1500 ft
Library
Lexington Public Library Ceiling Clock and Foucault Pendulum
900 ft
Shopping Area
Victorian Square Shoppes
1200 ft
Square
Phoenix Park
600 ft
Gallery
Limestone Blue
500 ft
Lexington Financial Center
Isaac Murphy Memorial Art Garden
500 ft
Gallery
Pam Miller Downtown Arts Center
800 ft
Gallery
ArtsPlace
800 ft
7285 Huron Street
Huron Street Gallery
900 ft
Gratz Park
1700 ft
Restaurants
Bourbon on Rye
300 ft
115 W Main St
Corto Lima
600 ft
101 West Short Street Corner of West Short and North Limestone Streets
School Sushi
400 ft
163 West Short Street
Bluegrass Tavern
500 ft
115 Cheapside
Horse And Jockey
700 ft
131 Cheapside
Buddha Lounge
700 ft
109 N Mill St
Explore Lexington
Experience Lexington
Top Attractions
Activities
Dining
Entertainment
Mary Todd Lincoln House
Mary Todd Lincoln House
9 minutes' walk
Historic site and childhood home of Mary Todd Lincoln, showcasing Lincoln family memorabilia and guided tours available.
Rupp Arena
Rupp Arena
6 minutes' walk
Multi-purpose arena hosting sports events, concerts, and shows, notable for its vibrant ambiance and large capacity.
Lexington Cemetery
Lexington Cemetery
4 minutes' drive
Beautifully landscaped cemetery with rich history, featuring notable figures and serene pathways for reflection.
University of Kentucky Art Museum
University of Kentucky Art Museum
13 minutes' walk
Art museum featuring collections from various periods, often hosting free admission days and special events.
Horse Country Tours
12 minutes' walk
Guided tours of horse farms showcasing thoroughbreds; perfect for horse enthusiasts looking for an authentic Kentucky experience.
McConnell Springs Park
5 minutes' drive
Nature park featuring trails and historical sites, ideal for hiking and relaxing in a beautiful outdoor setting.
Bourbon on Rye
Bourbon on Rye
1 minute' walk
Local favorite known for its craft cocktails and modern twist on Southern cuisine in a casual, stylish setting.
Corto Lima
Corto Lima
3 minutes' walk
Vibrant eatery serving Latin-inspired dishes, with a focus on fresh ingredients and creative flavors; reservations recommended.
Kentucky Theatre
Kentucky Theatre
5 minutes' walk
Historic theatre showcasing indie films, classic movies, and live performances; a great spot for all ages.
Manchester Music Hall
Manchester Music Hall
15 minutes' walk
Popular venue for live music and events, known for its lively atmosphere and featuring various artists throughout the year.
Getting around
City Centre
Lexington5 min  ·  1400 ft
Airports
Blue Grass (LEX)21 min  ·  8.5 mi
Want to see Exclusive Early Booking Rate?
Get exlusive rates right now!
Check Rates
Property information and rules
Check-in
from 16:00-23:59
Check-out
until 11 am
Guest Parking
No parking available.
Internet
Wireless internet is available in public areas for free.
Children & extra beds
There are no extra beds provided in a room.  There are no cots provided in a room. 
Pets
Pets are allowed on request.
Number of floors:
15
Number of rooms:
88

Reviews and Ratings

Feedback about 21C Museum Hotel Lexington from previous guests about their experience.
Review score
Based on 276 verified reviews
8.2/10
Great
77%
Recommend
Cleanliness
8.7/10
Comfort
8.6/10
Facilities
8.4/10
Free Wi-Fi
8.1/10
Location
9.0/10
Staff
8.7/10
Value for money
7.8/10
Guest reviews
based on 299 reviews
8.3/10
No reviews yet on our siteUnfortunately, our guests have not yet left any reviews for this hotel, but you can read reviews from Booking.com.
Open reviews
FAQs
About 21C Museum Hotel Lexington
What are the check-in and check-out times at 21C Museum Hotel Lexington?
Check-in is at 16:00 and check-out is by 11:00.
What fitness facilities are available at 21C Museum Hotel Lexington?
Guests have access to a fitness center and yoga classes.
What are the dining options at 21C Museum Hotel Lexington?
The hotel features on-site dining at Lockbox restaurant and a bar/lounge area.
Which nearby attractions are within walking distance of 21C Museum Hotel Lexington?
Nearby attractions include Rupp Arena (0.5 km) and the Lexington Convention Center (0.5 km).
What amenities do the rooms at 21C Museum Hotel Lexington offer?
Rooms include air conditioning, a flat-screen TV, a desk, and a private bathroom.
Is there a business center available at 21C Museum Hotel Lexington?
The hotel features a business center for guests needing business services.
What is the closest airport to 21C Museum Hotel Lexington?
The hotel is located 9 km from Blue Grass Airport.
What room views are available at 21C Museum Hotel Lexington?
Certain rooms offer views of the city.
Are there any children's menu options at 21C Museum Hotel Lexington?
A children's menu is available at the on-site restaurant.
What recreational opportunities are available for guests at 21C Museum Hotel Lexington?
Guests can participate in temporary art galleries, local culture tours, and walking tours.
Where can I find nearby restaurants while staying at 21C Museum Hotel Lexington?
Nearby restaurants include Infinity (0.5 km), Nat's (0.5 km), and Dudley's On Short (0.5 km).

Next best alternative

Consider them for your next trip.
Check-in
20Apr2026Select date
Check-out
21Apr2026Select date
Rooms and Guests2 Guests, 1 Room