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From108US$ /night
Check-in
10Jan2026Select date
Check-out
11Jan2026Select date
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

109 Matthews Lane, Sikeston, Missouri, United States, 63801
-
Near the Sikeston Depot Museum & Gallery
Great
8.1
8.0
/10
3.7
3.6
/5

Amenities

The hotel offers a variety of facilities including a 24-hour fitness center and an indoor pool for year-round enjoyment. A business center is accessible for guests needing work facilities, equipped with printing and fax services. In addition, the hotel provides free parking for all vehicles, including trucks and buses.

Rooms

The hotel includes 70 guest rooms and suites, each equipped with microwaves and refrigerators for convenience. Select rooms offer additional space and separate areas to accommodate families and groups. All accommodations are designed with practical amenities, ensuring a comfortable stay.

Location

Comfort Inn & Suites Sikeston is conveniently located off Interstate 55, making it easily accessible for travelers. The hotel is situated within a few minutes' drive to popular attractions like the Sikeston Factory Outlet Stores. The area offers dining options and local shops within close proximity.

Business

The hotel caters to business travelers with a well-equipped meeting room that can accommodate up to 50 guests. High-speed internet is available throughout the hotel to support remote work and virtual meetings. Additional business services are offered to enhance productivity during stays.

Dining

Guests can enjoy a fresh and free hot breakfast each morning, offering both hot and cold selections to start the day right. A vending area is available on-site for quick snacks and beverages. Local restaurants are nearby to provide further dining options during their stay.

Highlights

Location: Off Interstate 55, easily accessible

Rooms: 70 guest rooms and suites

Amenities: Indoor pool & 24-hour fitness center

Business: Meeting room for 50 guests

Dining: Fresh and free hot breakfast

Must-do experiences

  • Savor a barbecue feast at The Rib City Grill for local flavors.
  • Visit the Sikeston Depot Museum for unique local history.
  • Try the signature Toasted Ravioli at Lamberts Cafe.
  • Catch a performance at the Sikeston Little Theatre for fun nightlife.
  • Explore the Sikeston Farmers Market for fresh local produce.
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Select your room type

The hotel offers a variety of rooms including double rooms, family rooms, and suites with breakfast, free cancelations, and special deals
King Room Non-Smoking
2 persons
33 m² 
1 King-size bed
King Suite Non-Smoking
2 persons
33 m² 
1 King-size bed
Queen Room Two Queen Beds Non-Smoking
2 persons
33 m² 
2 King Size Beds
King Room Accessible or Non-Smoking
2 persons
1 King-size bed
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Facilities

The hotel offers amenities for your comfortable stay and unforgettable experiences

General

  • Free Wi-Fi
  • Parking
  • Safe deposit box
  • Pets allowed

Children

  • Cots

Spa & Leisure

  • Indoor swimming pool

Bathroom

  • Washing machine

Media

  • AM/FM alarm clock
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Location

109 Matthews Lane, Sikeston, Missouri, United States, 63801
Map view
109 Matthews Lane, Sikeston, Missouri, United States, 63801
Restaurants
El Nopalito Grill
260 m
2600 E Malone Ave
Explore Sikeston
Local Highlights
Top Attractions
Activities
Dining
Entertainment
Sikeston Depot Museum & Gallery
Sikeston Depot Museum & Gallery
10-minute drive
Sikeston Depot Museum showcases local history and culture with exhibits and a railway theme. A great spot for history enthusiasts.
Malco Sikeston Cinema
10-minute drive
Catch the latest films at Malco Sikeston Cinema, featuring comfortable seating and on-site dining for a fun movie night experience.
Boot Heel Golf Club
10-minute drive
Boot Heel Golf Club offers a challenging 18-hole course that caters to all skill levels, perfect for golf lovers seeking relaxation.
Sikeston Sports Complex
10-minute drive
Sikeston Sports Complex features fields for various sports, ideal for families or friends looking to enjoy outdoor games together.
Relaxing Day Spa
10-minute drive
Enjoy relaxation at a local day spa offering massages and wellness treatments, perfect for those seeking a serene escape.
El Nopalito Grill
El Nopalito Grill
4-minute walk
El Nopalito Grill serves authentic Mexican cuisine in a vibrant setting, famous for its tacos and margaritas. Reservations recommended.
Sikeston Jaycee Bootheel Rodeo
10-minute drive
A seasonal dining option during the rodeo festival featuring local flavors and crafts, perfect for a cultural culinary experience.
Malco Sikeston Cinema and Grill
Malco Sikeston Cinema and Grill
10-minute drive
Enjoy dinner and a movie at Malco, featuring live music nights and themed film festivals for a fun night out.
Central Park Events
10-minute drive
Central Park hosts various family-friendly events throughout the year, including concerts and seasonal festivals for all ages.
Getting around
City Centre
Sikeston8 min  ·  4.8 km
Airports
Cape Girardeau Regional Airport (CGI)65 min  ·  43.0 km
Barkley Regional Airport (PAH)135 min  ·  89.8 km
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Property information and rules
Check-in
from 14:00-23:59
Check-out
until 11 am
Guest Parking
Private parking is possible on site for free.
Internet
is available in for free.
Breakfast
A buffet breakfast is served at affordable prices. 
Children & extra beds
There are no cots provided in a room. 
Pets
Pets are allowed on request.
Year renovated:
2007
Number of rooms:
64
FAQs
About Comfort Inn & Suites Sikeston I-55
What is the policy for arriving and departing at Comfort Inn & Suites Sikeston I-55?
Check-in is at 14:00 and check-out is by 11:00.
Does Comfort Inn & Suites Sikeston I-55 offer free breakfast?
A complimentary American breakfast is served daily.
Is parking available at Comfort Inn & Suites Sikeston I-55?
Free private parking is available on-site without the need for a reservation.
What amenities are available for exercise at Comfort Inn & Suites Sikeston I-55?
Guests have access to an on-site exercise room and an indoor heated pool.
Are pets allowed at Comfort Inn & Suites Sikeston I-55?
Pets are allowed with applicable charges.
What room amenities are offered at Comfort Inn & Suites Sikeston I-55?
Rooms include air conditioning, refrigerators, microwaves, coffee makers, and flat-screen televisions.
Which nearby attractions are close to Comfort Inn & Suites Sikeston I-55?
Nearby attractions include Bootheel Golf Club, Sikeston Depot Museum & Gallery, and Veterans Park.
What dining options are available near Comfort Inn & Suites Sikeston I-55?
Dining options include McDonald's and Lambert's Café, famous for their 'throwed rolls,' located less than 1 km away.
Is Wi-Fi available at Comfort Inn & Suites Sikeston I-55?
Free high-speed Wi-Fi is available throughout the hotel.
What business services are available at Comfort Inn & Suites Sikeston I-55?
The hotel features a business center with copy and fax services and public computer access.
How far is the nearest airport from Comfort Inn & Suites Sikeston I-55?
Cape Girardeau Regional Airport is located 45 km away.

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