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From108US$ /night
Check-in
25Nov2025Select date
Check-out
26Nov2025Select date
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

109 Matthews Lane, Sikeston, Missouri, United States, 63801
-
Near the Sikeston Depot Museum & Gallery

Amenities

The hotel offers a variety of facilities including a 24-hour fitness center and an indoor pool for year-round enjoyment. A business center is accessible for guests needing work facilities, equipped with printing and fax services. In addition, the hotel provides free parking for all vehicles, including trucks and buses.

Rooms

The hotel includes 70 guest rooms and suites, each equipped with microwaves and refrigerators for convenience. Select rooms offer additional space and separate areas to accommodate families and groups. All accommodations are designed with practical amenities, ensuring a comfortable stay.

Location

Comfort Inn & Suites Sikeston is conveniently located off Interstate 55, making it easily accessible for travelers. The hotel is situated within a few minutes' drive to popular attractions like the Sikeston Factory Outlet Stores. The area offers dining options and local shops within close proximity.

Business

The hotel caters to business travelers with a well-equipped meeting room that can accommodate up to 50 guests. High-speed internet is available throughout the hotel to support remote work and virtual meetings. Additional business services are offered to enhance productivity during stays.

Dining

Guests can enjoy a fresh and free hot breakfast each morning, offering both hot and cold selections to start the day right. A vending area is available on-site for quick snacks and beverages. Local restaurants are nearby to provide further dining options during their stay.

Highlights

Location: Off Interstate 55, easily accessible

Rooms: 70 guest rooms and suites

Amenities: Indoor pool & 24-hour fitness center

Business: Meeting room for 50 guests

Dining: Fresh and free hot breakfast

Must-do experiences

  • Savor a barbecue feast at The Rib City Grill for local flavors.
  • Visit the Sikeston Depot Museum for unique local history.
  • Try the signature Toasted Ravioli at Lamberts Cafe.
  • Catch a performance at the Sikeston Little Theatre for fun nightlife.
  • Explore the Sikeston Farmers Market for fresh local produce.
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Select your room type

The hotel offers a variety of rooms including double rooms, family rooms, and suites with breakfast, free cancelations, and special deals
King Room Non-Smoking
2 persons
33 m² 
1 King-size bed
King Suite Non-Smoking
2 persons
33 m² 
1 King-size bed
Queen Room Two Queen Beds Non-Smoking
2 persons
33 m² 
2 King Size Beds
King Room Accessible or Non-Smoking
2 persons
1 King-size bed
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Getting around

A list of all available modes of transport

City Centre
Sikeston 4.8 km
Airports
Cape Girardeau Regional (CGI) 43.0 km
Barkley Regional (PAH) 89.8 km

Facilities

The hotel offers amenities for your comfortable stay and unforgettable experiences

General

  • Free Wi-Fi
  • Parking
  • Safe deposit box
  • Pets allowed

Children

  • Cots

Spa & Leisure

  • Indoor swimming pool

Bathroom

  • Washing machine

Media

  • AM/FM alarm clock
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Location

109 Matthews Lane, Sikeston, Missouri, United States, 63801
Map view
109 Matthews Lane, Sikeston, Missouri, United States, 63801
Restaurants
El Nopalito Grill
260 m
2600 E Malone Ave
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FAQs
About Comfort Inn & Suites Sikeston I-55
Check-in
25Nov2025Select date
Check-out
26Nov2025Select date
Rooms and Guests2 Guests, 1 Room