Comfort Inn & Suites Sikeston I-55 Exterior photoComfort Inn & Suites Sikeston I-55 Exterior photoComfort Inn & Suites Sikeston I-55 Exterior photo
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From108US$ /night
Check-in
20Apr2026Select date
Check-out
21Apr2026Select date
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

109 Matthews Lane, Sikeston, Missouri, United States, 63801
-
Near the Sikeston Depot Museum & Gallery
Very good
7.9
8.1
/10
3.6
3.6
/5

Amenities

Comfort Inn & Suites Sikeston I-55 offers guests an indoor heated pool, a fitness center, and a business center equipped for productivity. The hotel provides a fresh and free hot breakfast including a variety of items like scrambled eggs, sausage, and waffles. Guests can also take advantage of on-site laundry facilities for added convenience.

Rooms

This hotel features a range of room types, including family accommodations with two queen beds and king suites with pull-out sofas for added comfort. Each room includes a flat-screen television, refrigerator, and microwave for convenience during any stay. Some suites also boast a separate living area and additional space for relaxation.

Location

Located off Interstate 55, the hotel provides easy access to popular attractions such as the Sikeston Depot Museum and the Sikeston Rodeo grounds. The hotel's proximity to nearby restaurants and shopping centers enhances the convenience for guests. It serves as a great base for exploring the local area and its attractions.

Business

The hotel accommodates business travelers with a well-equipped business center featuring computers and printing services. Meeting spaces are available for small gatherings or conferences. High-speed internet access ensures seamless connectivity throughout the facilities.

Family-Friendly Features

Children can enjoy the indoor pool, which provides a fun swimming experience year-round. Nearby family-friendly attractions include the Kern Memorial Park and the Poplar Bluff Riverfront. The hotel provides spacious rooms to comfortably accommodate families during their stay.

Highlights

Amenities: Indoor heated pool and fitness center

Dining: Fresh and free hot breakfast

Rooms: King suites with pull-out sofas

Location: Easy access to Sikeston Depot Museum

Business: Well-equipped business center

Family-Friendly: Indoor pool and spacious accommodations

Must-do experiences

  • Savor a barbecue feast at The Rib City Grill for local flavors.
  • Visit the Sikeston Depot Museum for unique local history.
  • Try the signature Toasted Ravioli at Lamberts Cafe.
  • Catch a performance at the Sikeston Little Theatre for fun nightlife.
  • Explore the Sikeston Farmers Market for fresh local produce.
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Select your room type

Comfort Inn & Suites Sikeston I-55 offers a variety of rooms including double rooms, family rooms, and suites with breakfast, free cancelations, and special deals
King Room Non-Smoking
2 persons
360 sq. feet 
1 King-size bed
King Suite Non-Smoking
2 persons
360 sq. feet 
1 King-size bed
Queen Room Two Queen Beds Non-Smoking
2 persons
360 sq. feet 
2 King Size Beds
King Room Accessible or Non-Smoking
2 persons
1 King-size bed
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Facilities

Comfort Inn & Suites Sikeston I-55 offers amenities for your comfortable stay and unforgettable experiences
Facilities: Very good
7.8/10Review score

General

  • Wi-Fi
  • Free parking
  • Safe deposit box
  • Pets allowed

Children

  • Cots

Spa & Leisure

  • Indoor swimming pool

Bathroom

  • Washing machine

Media

  • AM/FM alarm clock
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Comfort Inn & Suites Sikeston I-55 Location

109 Matthews Lane, Sikeston, Missouri, United States, 63801
Map view
109 Matthews Lane, Sikeston, Missouri, United States, 63801
Restaurants
El Nopalito Grill
900 ft
2600 E Malone Ave
Explore Sikeston
Local Highlights
Top Attractions
Activities
Dining
Entertainment
Sikeston Depot Museum & Gallery
Sikeston Depot Museum & Gallery
10-minute drive
Sikeston Depot Museum showcases local history and culture with exhibits and a railway theme. A great spot for history enthusiasts.
Malco Sikeston Cinema
10-minute drive
Catch the latest films at Malco Sikeston Cinema, featuring comfortable seating and on-site dining for a fun movie night experience.
Boot Heel Golf Club
10-minute drive
Boot Heel Golf Club offers a challenging 18-hole course that caters to all skill levels, perfect for golf lovers seeking relaxation.
Sikeston Sports Complex
10-minute drive
Sikeston Sports Complex features fields for various sports, ideal for families or friends looking to enjoy outdoor games together.
Relaxing Day Spa
10-minute drive
Enjoy relaxation at a local day spa offering massages and wellness treatments, perfect for those seeking a serene escape.
El Nopalito Grill
El Nopalito Grill
4-minute walk
El Nopalito Grill serves authentic Mexican cuisine in a vibrant setting, famous for its tacos and margaritas. Reservations recommended.
Sikeston Jaycee Bootheel Rodeo
10-minute drive
A seasonal dining option during the rodeo festival featuring local flavors and crafts, perfect for a cultural culinary experience.
Malco Sikeston Cinema and Grill
Malco Sikeston Cinema and Grill
10-minute drive
Enjoy dinner and a movie at Malco, featuring live music nights and themed film festivals for a fun night out.
Central Park Events
10-minute drive
Central Park hosts various family-friendly events throughout the year, including concerts and seasonal festivals for all ages.
Getting around
City Centre
Sikeston8 min  ·  3.0 mi
Airports
Cape Girardeau Regional (CGI)65 min  ·  26.7 mi
Barkley Regional (PAH)135 min  ·  55.9 mi
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Property information and rules
Check-in
from 14:00-23:59
Check-out
until 11 am
Guest Parking
Private parking is possible on site for free.
Internet
Wireless internet is available in for free.
Breakfast
A buffet breakfast is served at affordable prices. 
Children & extra beds
There are no cots provided in a room. 
Pets
Pets are allowed on request.
Year renovated:
2007
Number of rooms:
64

Reviews and Ratings

Feedback about Comfort Inn & Suites Sikeston I-55 from previous guests about their experience.
Review score
Based on 134 verified reviews
8.0/10
Great
79%
Recommend
Cleanliness
8.1/10
Comfort
8.1/10
Facilities
7.8/10
Free Wi-Fi
5.5/10
Location
8.6/10
Staff
8.5/10
Value for money
7.9/10
Guest reviews
based on 188 reviews
7.9/10
No reviews yet on our siteUnfortunately, our guests have not yet left any reviews for this hotel, but you can read reviews from Booking.com.
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FAQs
About Comfort Inn & Suites Sikeston I-55
What is the policy for arriving and departing at Comfort Inn & Suites Sikeston I-55?
Check-in is at 14:00 and check-out is by 11:00.
Does Comfort Inn & Suites Sikeston I-55 offer free breakfast?
A complimentary American breakfast is served daily.
Is parking available at Comfort Inn & Suites Sikeston I-55?
Free private parking is available on-site without the need for a reservation.
What amenities are available for exercise at Comfort Inn & Suites Sikeston I-55?
Guests have access to an on-site exercise room and an indoor heated pool.
Are pets allowed at Comfort Inn & Suites Sikeston I-55?
Pets are allowed with applicable charges.
What room amenities are offered at Comfort Inn & Suites Sikeston I-55?
Rooms include air conditioning, refrigerators, microwaves, coffee makers, and flat-screen televisions.
Which nearby attractions are close to Comfort Inn & Suites Sikeston I-55?
Nearby attractions include Bootheel Golf Club, Sikeston Depot Museum & Gallery, and Veterans Park.
What dining options are available near Comfort Inn & Suites Sikeston I-55?
Dining options include McDonald's and Lambert's Café, famous for their 'throwed rolls,' located less than 1 km away.
Is Wi-Fi available at Comfort Inn & Suites Sikeston I-55?
Free high-speed Wi-Fi is available throughout the hotel.
What business services are available at Comfort Inn & Suites Sikeston I-55?
The hotel features a business center with copy and fax services and public computer access.
How far is the nearest airport from Comfort Inn & Suites Sikeston I-55?
Cape Girardeau Regional Airport is located 45 km away.

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Check-in
20Apr2026Select date
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Rooms and Guests2 Guests, 1 Room