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From209US$ /night
Check-in
09Jan2026Select date
Check-out
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Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

700 West Main Street, Louisville, Kentucky, United States, 40202
-
Steps from the Ohio River
Great
8.7
9.3
/10
4.7
4.6
/5

Rooms & Suites

21C Museum Hotel Louisville offers a variety of guest rooms and suites that capture the essence of its historical surroundings. Each room showcases original artwork and comes equipped with high-definition televisions, ensuring a captivating atmosphere. Unique offerings include the Asleep in The Cyclone immersive artist suite, featuring a king-sized platform bed and curated record collection.

Dining & Drinks

Proof on Main serves southern and Appalachian-inspired cuisine, led by Executive Chef Cody Stone. This dining institution ranks as one of the best bourbon bars in the country and offers the 21c Selects Private Barrel Program. Guests can enjoy specialty brews and culinary creations that reflect the region's rich culinary heritage.

Art Museum

21C Museum Hotel integrates art into the guest experience with curated exhibitions available around the clock and free of charge. The hotel preserves a commitment to contemporary art with dynamic installations reflecting its global nature. Special artistic experiences, such as the immersive Asleep in The Cyclone, provide guests with unique perspectives.

Wellness

The Spa at 21C provides a range of massage treatments, including Swedish and deep tissue options. Guests can access sauna and steam room facilities, enhancing their relaxation experience. Wellness offerings also feature custom massages tailored to individual needs, encouraging overall well-being.

Location

Situated on Museum Row in downtown Louisville, 21C Museum Hotel places guests near major attractions. The hotel is located steps from the Louisville Slugger Museum, Kentucky Performing Arts Center, and numerous local galleries. This prime location allows guests to explore the dynamic culture of the city easily.

Highlights

Location: Steps from major attractions

Dining: One of the best bourbon bars

Rooms: Immersive artist suites

Wellness: Range of massage treatments

Must-do experiences

  • Savor the Hot Brown at the Brown Hotel for a true local delight.
  • Visit the Muhammad Ali Center for inspiration and cultural insight.
  • Explore the quirky exhibits at the Speed Art Museum downtown.
  • Stroll through NuLu for trendy shops and unique local art.
  • Don't miss the Louisville Mega Cavern tours for an underground adventure.
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Select your room type

The hotel offers a variety of rooms including double rooms, family rooms, and suites with breakfast, free cancelations, and special deals
Room Balcony
2 persons
29 m² 
1 King-size bed
Shower
Coffee machine
Deluxe King Room
2 persons
31 m² 
1 King-size bed
Shower
Coffee machine
Corner Suite
2 persons
61 m² 
1 King-size bed
Shower
Coffee machine
Deluxe King Suite
2 persons
46 m² 
1 King-size bed
Shower
Coffee machine
Click button to see more rooms
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Price and Room Availability Calendar

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Facilities

The hotel offers amenities for your comfortable stay and unforgettable experiences

General

  • No smoking on site
  • Free Wi-Fi
  • Parking
  • Safe deposit box
  • 24-hour reception
  • Pets allowed
  • Rooms/ Facilities for disabled
  • Wheelchair access
  • Security
  • Luggage storage
  • Locker room
  • Allergy-free rooms
  • Lift
  • ATM/Cash machine
  • Smoke detectors
  • Electric vehicle charging station
  • Fire extinguishers

Sports & Fitness

  • Fitness centre
  • Yoga class

Guest Parking

  • Cookware/ Kitchen utensils

Services

  • Valet parking
  • Room service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Welcome drink

Dining

  • Restaurant
  • Bar/ Lounge area
  • Outdoor dining area

Business

  • Business centre
  • Meeting/ Banquet facilities
  • Fax/Photocopying

Children

  • Cots

Spa & Leisure

  • Spa & wellness centre
  • Sauna
  • Turkish bath
  • Steam room
  • Full body massage

Room features

  • Air conditioning
  • Heating
  • Mini-bar
  • Soundproofed rooms
  • Patio
  • Tea and coffee facilities
  • Ironing facilities

Bathroom

  • Free toiletries

Self-catering

  • Cookware/ Kitchen utensils

Media

  • Flat-screen TV

Room decor

  • Carpeted floor
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Dining Onsite

Proof on Main offers a modern American dining experience that highlights local flavors and innovative culinary techniques. Nestled within a vibrant setting, it serves as a gateway to unique events, such as the Fork & Bottle dinner series featuring regional distillers and the celebrated annual Hog & Barrel dinner showcasing Pappy Van Winkle.
21C Museum Hotel Louisville Restaurant photo
21C Museum Hotel Louisville Restaurant photo
21C Museum Hotel Louisville Restaurant photo

Proof on Main

American
Ambiance
Contemporary setting with artistic touches and an inviting atmosphere perfect for gatherings or intimate meals.
Key Offerings
Signature dishes highlight local ingredients, complemented by an extensive selection of craft cocktails and a curated wine list. Special events like the Fork & Bottle dinner series and Hog & Barrel dinner offer exclusive pairings with renowned spirits.
Reservation
Reservations recommended.
Hours vary.

Location

700 West Main Street, Louisville, Kentucky, United States, 40202
Map view
700 West Main Street, Louisville, Kentucky, United States, 40202
Nearby
Museum
Louisville Slugger Museum & Bat Factory
180 m
Museum
Muhammad Ali Center
280 m
Museum
Kentucky Science Center
140 m
Museum
The Frazier History Museum
260 m
Museum
Kentucky Museum of Art and Craft
70 m
528 W Main St
Evan Williams Bourbon Experience
200 m
Gallery
Flame Run Glass Studio and Gallery
300 m
500 W Main St
The Belvedere
250 m
Night club
Jimmy Can't Dance
90 m
801 W Main St
Michter's Fort Nelson Distillery
150 m
Library
Sons of the American Revolution Genealogical Research Library
190 m
120 N 10th St
Kentucky Peerless Distilling Co
480 m
401 W River Rd
Belle of Louisville Riverboats
580 m
Restaurants
Proof On Main
10 m
702 West Main Street
Mussel & Burger Bar Downtown
60 m
113 S 7th St Located in Louisville's Central Business District
Bristol Bar & Grille
110 m
614 W Main St
Atlantic No. 5
160 m
605 W Main St Located in Louisville's Central Business District.
Los Aztecas Mexican Restaurant
180 m
445 E Market St
Vincenzo's Italian Restaurant
430 m
150 S 5th St
Jockey Silks Bourbon Bar
480 m
140 N 4th St 2nd Floor - West Tower
Dish on Market
470 m
434 W Market St
Quiznos
540 m
223 S 5th St
Swizzle Dinner & Drinks
530 m
140 N Fourth St 25th Floor
Cafe Magnolia
590 m
140 N 4th St Galt House Hotel
Explore Louisville
Local Experiences
Top Attractions
Activities
Dining
Entertainment
Kentucky Science Center
Kentucky Science Center
2 minutes walking
Interactive science exhibits and IMAX films make this center a fun spot for families and curious minds.
Louisville Slugger Museum & Bat Factory
Louisville Slugger Museum & Bat Factory
3 minutes walking
Home of the iconic baseball bat, offering tours and unique memorabilia that baseball fans won't want to miss.
Muhammad Ali Center
Muhammad Ali Center
4 minutes walking
A cultural and educational center honoring the legacy of Muhammad Ali with exhibits on peace, social justice, and boxing.
Waterfront Park
Waterfront Park
17 minutes walking
Expansive green space along the river featuring walking trails, picnic areas, and stunning city views.
Louisville Waterfront Park Activities
17 minutes walking
Outdoor concerts and recreational activities abound in this scenic park, perfect for relaxation and family fun.
Angel's Envy Distillery Tour
19 minutes walking
A unique guided experience of bourbon distilling with tastings. Closed-toed shoes recommended for safety.
Proof On Main
Proof On Main
1 minute walking
Farm-to-table restaurant featuring regional cuisine and an extensive wine list in a contemporary setting.
Mussel & Burger Bar Downtown
Mussel & Burger Bar Downtown
1 minute walking
Casual eatery specializing in gourmet burgers and mussels, with a laid-back vibe and local craft beers.
Bristol Bar & Grille
Bristol Bar & Grille
2 minutes walking
Offering a diverse menu with Southern classics and a cozy atmosphere, perfect for a family dinner or casual lunch.
KFC Yum Center
KFC Yum Center
9 minutes walking
This venue hosts major concerts and sporting events, featuring a dynamic atmosphere and fantastic sound quality.
Fourth Street Live!
10 minutes walking
An entertainment district buzzing with restaurants, bars, and live music events, great for nightlife and socializing.
Getting around
City Centre
Louisville23 min  ·  1.9 km
Airports
Louisville International Airport (SDF)18 min  ·  11.9 km
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Property information and rules
Check-in
from 16:00-23:59
Check-out
until 11 am
Guest Parking
No parking available.
Internet
is available in for free.
Children & extra beds
Maximum capacity of extra beds in a room is 1. 
Pets
Pets are allowed on request.
Year renovated:
2006
Number of floors:
4
Number of rooms:
96
Former name
21c Museum Hotel
FAQs
About 21C Museum Hotel Louisville
What is the check-in and check-out policy at 21C Museum Hotel Louisville?
Check-in is at 16:00 and check-out is at 11:00.
Is parking available at 21C Museum Hotel Louisville?
Valet parking is offered on-site.
What room amenities are available at 21C Museum Hotel Louisville?
Rooms include free Wi-Fi, a 50-inch flat-screen TV, minibar, coffee and tea making facilities, and a writing desk.
What dining options are available at 21C Museum Hotel Louisville?
The hotel features the on-site restaurant, Proof on Main, which offers unique Southern cuisine.
What fitness and wellness facilities does 21C Museum Hotel Louisville provide?
Guests have access to a fitness center, spa and wellness services, a sauna, and a steam room.
What nearby attractions are within walking distance of 21C Museum Hotel Louisville?
Nearby attractions include the Muhammad Ali Center, Louisville Slugger Museum & Factory, and the Frazier International History Museum, all within 1 km.
Which nearby restaurants are close to 21C Museum Hotel Louisville?
Popular nearby restaurants include Main Eatery, Bristol Bar & Grille, Mussel & Burger Bar, and Morton's The Steakhouse, all within 0.5 km.
Does 21C Museum Hotel Louisville provide business services?
The hotel offers a business center and meeting rooms for corporate events.
How far is 21C Museum Hotel Louisville from Louisville International Airport?
The hotel is located 10 km from Louisville International Airport.
What types of massages are available at 21C Museum Hotel Louisville?
Guests can select from deep tissue massage and sports massage among other wellness treatments.
Does 21C Museum Hotel Louisville have an art museum on-site?
Yes, the hotel features a contemporary art museum with over 836.1 m² of exhibition space.
Is 21C Museum Hotel Louisville suitable for events?
The hotel has customizable event spaces and dedicated event staff for gatherings and celebrations.

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