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From200US$ /night
Check-in
25Nov2025Select date
Check-out
26Nov2025Select date
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

700 West Main Street, Louisville, Kentucky, United States, 40202
-
Steps from the Ohio River
Perfect
9.0
9.3
/10
4.7
4.6
/5

Rooms & Suites

21C Museum Hotel Louisville offers a variety of guest rooms and suites that capture the essence of its historical surroundings. Each room showcases original artwork and comes equipped with high-definition televisions, ensuring a captivating atmosphere. Unique offerings include the Asleep in The Cyclone immersive artist suite, featuring a king-sized platform bed and curated record collection.

Dining & Drinks

Proof on Main serves southern and Appalachian-inspired cuisine, led by Executive Chef Cody Stone. This dining institution ranks as one of the best bourbon bars in the country and offers the 21c Selects Private Barrel Program. Guests can enjoy specialty brews and culinary creations that reflect the region's rich culinary heritage.

Art Museum

21C Museum Hotel integrates art into the guest experience with curated exhibitions available around the clock and free of charge. The hotel preserves a commitment to contemporary art with dynamic installations reflecting its global nature. Special artistic experiences, such as the immersive Asleep in The Cyclone, provide guests with unique perspectives.

Wellness

The Spa at 21C provides a range of massage treatments, including Swedish and deep tissue options. Guests can access sauna and steam room facilities, enhancing their relaxation experience. Wellness offerings also feature custom massages tailored to individual needs, encouraging overall well-being.

Location

Situated on Museum Row in downtown Louisville, 21C Museum Hotel places guests near major attractions. The hotel is located steps from the Louisville Slugger Museum, Kentucky Performing Arts Center, and numerous local galleries. This prime location allows guests to explore the dynamic culture of the city easily.

Highlights

Location: Steps from major attractions

Dining: One of the best bourbon bars

Rooms: Immersive artist suites

Wellness: Range of massage treatments

Must-do experiences

  • Savor the Hot Brown at the Brown Hotel for a true local delight.
  • Visit the Muhammad Ali Center for inspiration and cultural insight.
  • Explore the quirky exhibits at the Speed Art Museum downtown.
  • Stroll through NuLu for trendy shops and unique local art.
  • Don't miss the Louisville Mega Cavern tours for an underground adventure.
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Select your room type

The hotel offers a variety of rooms including double rooms, family rooms, and suites with breakfast, free cancelations, and special deals
Room Balcony
2 persons
29 m² 
1 King-size bed
Shower
Coffee machine
Deluxe King Room
2 persons
31 m² 
1 King-size bed
Shower
Coffee machine
Corner Suite
2 persons
61 m² 
1 King-size bed
Shower
Coffee machine
Deluxe King Suite
2 persons
46 m² 
1 King-size bed
Shower
Coffee machine
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Price and Room Availability Calendar

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Getting around

A list of all available modes of transport

City Centre
Louisville 1.9 km
Airports
Louisville (SDF) 11.9 km

Facilities

The hotel offers amenities for your comfortable stay and unforgettable experiences

General

  • No smoking on site
  • Free Wi-Fi
  • Parking
  • Safe deposit box
  • 24-hour reception
  • Pets allowed
  • Rooms/ Facilities for disabled
  • Wheelchair access
  • Security
  • Luggage storage
  • Locker room
  • Allergy-free rooms
  • Lift
  • ATM/Cash machine
  • Smoke detectors
  • Electric vehicle charging station
  • Fire extinguishers

Sports & Fitness

  • Fitness centre
  • Yoga class

Guest Parking

  • Cookware/ Kitchen utensils

Services

  • Valet parking
  • Room service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Welcome drink

Dining

  • Restaurant
  • Bar/ Lounge area
  • Outdoor dining area

Business

  • Business centre
  • Meeting/ Banquet facilities
  • Fax/Photocopying

Children

  • Cots

Spa & Leisure

  • Spa & wellness centre
  • Sauna
  • Turkish bath
  • Steam room
  • Full body massage

Room features

  • Air conditioning
  • Heating
  • Mini-bar
  • Soundproofed rooms
  • Patio
  • Tea and coffee facilities
  • Ironing facilities

Bathroom

  • Free toiletries

Self-catering

  • Cookware/ Kitchen utensils

Media

  • Flat-screen TV

Room decor

  • Carpeted floor
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Dining Onsite

Proof on Main offers a modern American dining experience that highlights local flavors and innovative culinary techniques. Nestled within a vibrant setting, it serves as a gateway to unique events, such as the Fork & Bottle dinner series featuring regional distillers and the celebrated annual Hog & Barrel dinner showcasing Pappy Van Winkle.
21C Museum Hotel Louisville Restaurant photo
21C Museum Hotel Louisville Restaurant photo
21C Museum Hotel Louisville Restaurant photo

Proof on Main

American
Ambiance
Contemporary setting with artistic touches and an inviting atmosphere perfect for gatherings or intimate meals.
Key Offerings
Signature dishes highlight local ingredients, complemented by an extensive selection of craft cocktails and a curated wine list. Special events like the Fork & Bottle dinner series and Hog & Barrel dinner offer exclusive pairings with renowned spirits.
Reservation
Reservations recommended.
Hours vary.

Location

700 West Main Street, Louisville, Kentucky, United States, 40202
Map view
700 West Main Street, Louisville, Kentucky, United States, 40202
Nearby
Museum
Louisville Slugger Museum & Bat Factory
180 m
Museum
Muhammad Ali Center
280 m
Museum
Kentucky Science Center
140 m
Museum
The Frazier History Museum
260 m
Museum
Kentucky Museum of Art and Craft
70 m
528 W Main St
Evan Williams Bourbon Experience
200 m
Gallery
Flame Run Glass Studio and Gallery
300 m
500 W Main St
The Belvedere
250 m
Night club
Jimmy Can't Dance
90 m
801 W Main St
Michter's Fort Nelson Distillery
150 m
Library
Sons of the American Revolution Genealogical Research Library
190 m
120 N 10th St
Kentucky Peerless Distilling Co
480 m
401 W River Rd
Belle of Louisville Riverboats
580 m
Restaurants
Proof On Main
10 m
702 West Main Street
Mussel & Burger Bar Downtown
60 m
113 S 7th St Located in Louisville's Central Business District
Bristol Bar & Grille
110 m
614 W Main St
Atlantic No. 5
160 m
605 W Main St Located in Louisville's Central Business District.
Los Aztecas Mexican Restaurant
180 m
445 E Market St
Vincenzo's Italian Restaurant
430 m
150 S 5th St
Jockey Silks Bourbon Bar
480 m
140 N 4th St 2nd Floor - West Tower
Dish on Market
470 m
434 W Market St
Quiznos
540 m
223 S 5th St
Swizzle Dinner & Drinks
530 m
140 N Fourth St 25th Floor
Cafe Magnolia
590 m
140 N 4th St Galt House Hotel
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About 21C Museum Hotel Louisville
Check-in
25Nov2025Select date
Check-out
26Nov2025Select date
Rooms and Guests2 Guests, 1 Room