Book on our site
Up to 10% cheaper
than Booking.com
Check rooms and rates
From234US$ /night
Check-in
09Jan2026Select date
Check-out
10Jan2026Select date
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

1528 Locust Street, Saint Louis, Missouri, United States, 63103
-
Steps from the Gateway Arch
Great
8.5
8.9
/10
4.2
4.2
/5

Rooms & Suites

21C Museum Hotel St Louis offers art-filled rooms designed for rest and inspiration. The Luxury King Suite includes a separate living area, large windows, and a personal fitness loft. Unique room options such as the Love Birds package cater to couples seeking a romantic escape.

Culinary Experience

Dining at Idol Wolf presents a creative twist on Spanish tapas, utilizing local and seasonal ingredients. Guests can experience a shared drinking and dining atmosphere that celebrates regional culinary traditions. Room service is available for guests wishing to dine in the comfort of their rooms.

Art & Culture

21C Museum Hotel St Louis serves as a contemporary art museum, offering free access to curated exhibitions around the clock. Notable installations include Nick Cave's 'Until We Meet Again' and 'Elevate at 21c' showcasing artists like Marina Peng and Moraa N. Nyaribo. The hotel's art infuses everyday experiences and sparks dialogue within the community.

Wellness & Fitness

Locust Street Athletic and Swim Club within the hotel redefines wellness with a historic indoor lap pool and comprehensive fitness services. Guests can opt for personal training, group classes, and spa services designed for holistic health. The facility maintains the charm of its former life as a YMCA while providing modern fitness solutions.

Location & Community Impact

Located in downtown St. Louis, the hotel is just minutes from attractions such as Busch Stadium and the City Museum. 21C Museum Hotel actively partners with local businesses, promoting community engagement and improving local initiatives. Monthly nonprofit partnerships allow guests to give back through their stay.

Highlights

Rooms: Luxury King Suite with personal fitness loft

Culinary Experience: Idol Wolf offers Spanish tapas

Art & Culture: Contemporary art exhibitions open 24/7

Wellness: Historic indoor lap pool at Locust Street Athletic Club

Location: Minutes from Busch Stadium and City Museum

Must-do experiences

  • Visit Citygarden for art and beautiful landscapes in downtown St. Louis.
  • Try the St. Louis-style pizza at Imo's for a unique local flavor.
  • Explore the Anheuser-Busch Brewery for a beer history tour and tasting.
  • Stroll through the Missouri Botanical Garden for stunning plant displays.
  • Catch a show at The Fabulous Fox Theatre for a premier cultural experience.
View all

Select your room type

The hotel offers a variety of rooms including double rooms, family rooms, and suites with breakfast, free cancelations, and special deals
Deluxe King Room
2 persons
29 m² 
1 King-size bed
Shower
Heating
Deluxe King Suite Roll Shower Accessible
2 persons
47 m² 
1 King-size bed
Shower
Heating
Loft Two Queen Beds
2 persons
40 m² 
2 King Size Beds
Shower
Heating
Deluxe King Room Accessible
2 persons
29 m² 
1 King-size bed
Shower
Heating
Click button to see more rooms
Show all rooms
Show all roomsLess

Price and Room Availability Calendar

Check availability and prices for your dates now!

Facilities

The hotel offers amenities for your comfortable stay and unforgettable experiences

General

  • No smoking on site
  • Free Wi-Fi
  • Safe deposit box
  • 24-hour reception
  • VIP check-in/ -out
  • Pets allowed
  • Rooms/ Facilities for disabled
  • Wheelchair access
  • 24-hour security
  • Luggage storage
  • Locker room
  • Allergy-free rooms
  • Lift
  • ATM/Cash machine
  • Coffee shop
  • Vending machines
  • Smoke detectors
  • Fire extinguishers
  • Key card access

Sports & Fitness

  • Fitness centre
  • Billiard tables
  • Yoga class

Services

  • Valet parking
  • Room service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Welcome drink

Dining

  • Restaurant
  • Bar/ Lounge area
  • Special diet menus

Business

  • Business centre
  • Meeting/ Banquet facilities

Children

  • Cots
  • Board games
  • Game room

Facilities for people with disabilities

  • Toilet for disabled

Spa & Leisure

  • Indoor swimming pool
  • Leisure/ TV room
  • Spa & wellness centre
  • Steam room
  • Jacuzzi
  • Massage

Room features

  • Air conditioning
  • Heating
  • Soundproofed rooms
  • Sitting area
  • Terrace
  • Garden furniture

Bathroom

  • Free toiletries

Media

  • Flat-screen TV
Show more

Location

1528 Locust Street, Saint Louis, Missouri, United States, 63103
Map view
1528 Locust Street, Saint Louis, Missouri, United States, 63103
Nearby
Museum
City Museum
520 m
Museum
Campbell House Museum
90 m
Church
Christ Church Cathedral
430 m
1315 Chestnut St
Soldiers Memorial Military Museum
590 m
Aquarium
World Aquarium
400 m
Church
Centenary United Methodist Church
190 m
Night club
The Boom Boom Room
280 m
13th and Locust
Lucas Garden Park
350 m
Restaurants
The Last Kitchen
360 m
1501 Washington Ave Inside The Last Hotel
Red Oak Biscuits
310 m
1330 Washington Ave
Nara Cafe and Hookah Lounge
310 m
1326 Washington Ave
Flannery's
380 m
1324 Washington Ave
Rooftop Cafe at City Museum
400 m
701 N 15th St Fl 11
Lucas Park Grille
440 m
1234 Washington Avenue
Rosalita's Cantina
480 m
1235 Washington Avenue
Blondie's Coffee
450 m
1301 Washington Ave
Imo's Pizza
410 m
1828 Washington Ave
Papa John's Pizza
610 m
201 N Tucker Blvd Ste E
Bootleggin' BBQ
650 m
1933 Washington Ave
Explore Saint Louis
Explore St. Louis
Top Attractions
Activities
Dining
Entertainment
City Museum
City Museum
5 minutes walking
A whimsical playground featuring repurposed architectural elements. Great for all ages, with a rooftop view and unique installations.
Campbell House Museum
Campbell House Museum
2 minutes walking
A historical home showcasing rich St. Louis history. Visitors can view exquisite art and furnishings from the 19th century.
Stifel Theatre
Stifel Theatre
8 minutes walking
A beautifully restored venue hosting concerts and performances. Known for its intimate vibe and diverse programming for all tastes.
The Gateway Arch
The Gateway Arch
25 minutes walking
Iconic symbol of St. Louis with stunning views from the top. Offers educational exhibits on westward expansion in the visitor center.
Bike Riding at the Gateway Arch Grounds
25 minutes walking
Enjoy scenic bike paths around the Arch. Rentals are available nearby, making it easy to bike along the riverfront.
Relaxation at Compton Hill Reservoir Park
10 minutes driving
A serene park perfect for leisurely walks or picnics. Offers green spaces and a lovely reservoir for a quiet retreat.
Flannery's
Flannery's
5 minutes walking
A casual Irish pub known for its classic dishes and generous portions. Great atmosphere with craft beers and live music.
The Last Kitchen
The Last Kitchen
5 minutes walking
Offers seasonal American dishes with local ingredients. Cozy setting with a creative menu and outdoor seating available.
The National Blues Museum
16 minutes walking
Celebrates blues music's rich history in America. Features interactive exhibits and live performances. A must for music lovers.
Kiener Plaza
Kiener Plaza
8 minutes walking
A vibrant public space hosting events and art installations. Family-friendly with playgrounds and seating areas for relaxation.
Getting around
City Centre
Saint Louis8 min  ·  600 m
Airports
St. Louis Lambert International Airport (STL)33 min  ·  21.8 km
Belleville, IL (BLV)62 min  ·  40.8 km
Train
Union Station9 min  ·  700 m
Bus
Bus stop3 min  ·  200 m
Want to see Exclusive Early Booking Rate?
Get exlusive rates right now!
Check Rates
Property information and rules
Check-in
from 16:00-23:59
Check-out
until 11 am
Guest Parking
No parking available.
Internet
is available in for free.
Pets
Pets are allowed on request.
Number of floors:
10
Number of rooms:
137
FAQs
About 21C Museum Hotel St Louis
What is the distance from 21C Museum Hotel St Louis to St Louis Lambert International Airport?
The hotel is 21 km from St Louis Lambert International Airport.
What amenities does 21C Museum Hotel St Louis offer for fitness enthusiasts?
Guests have access to a fitness center, indoor swimming pool, hot tub, and yoga classes.
What dining options are available at 21C Museum Hotel St Louis?
The hotel features an on-site restaurant serving Spanish cuisine and a lounge bar for guests.
What are the check-in and check-out times at 21C Museum Hotel St Louis?
Check-in time is 16:00 and check-out time is 11:00.
What nearby attractions can guests visit from 21C Museum Hotel St Louis?
Nearby attractions include the Gateway Arch (3 km), Old Courthouse (2 km), and Laclede's Landing (2 km).
Does 21C Museum Hotel St Louis provide free Wi-Fi?
Complimentary Wi-Fi is available throughout the property.
What are some popular restaurants near 21C Museum Hotel St Louis?
Popular restaurants within 0.5 km include Samwiches, Rooftop Cafe at City Museum, and Flannery's.
What room amenities can guests expect at 21C Museum Hotel St Louis?
Rooms feature air conditioning, a flat-screen TV with cable channels, a safe deposit box, and a private bathroom.
Does 21C Museum Hotel St Louis offer any spa services?
The hotel features a spa and wellness center with massage services and steam room.
Is valet parking available at 21C Museum Hotel St Louis?
Valet parking service is available for guests.

Next best alternative

Consider them for your next trip.
Check-in
09Jan2026Select date
Check-out
10Jan2026Select date
Rooms and Guests2 Guests, 1 Room
Need more options?
Check Top hotels near 21C Museum Hotel St Louis
St. Louis Union Station Hotel, Curio Collection By Hilton Exterior photo
Mobile-only price

St. Louis Union Station Hotel, Curio Collection By Hilton

8.2
Great503 reviews
487m from property
USD 150USD 135
per night
Drury Inn And Suites St Louis Union Station Saint Louis Exterior photo
Mobile-only price

Drury Inn And Suites St Louis Union Station Saint Louis

8.9
Great1417 reviews
761m from property
USD 128USD 115
per night
Fairfield Inn And Suites By Marriott St Louis Downtown Saint Louis Exterior photo
Mobile-only price

Fairfield Inn And Suites By Marriott St Louis Downtown Saint Louis

8.8
Great385 reviews
868m from property
USD 152USD 136
per night