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From332US$ /night
Check-in
18Mar2026Select date
Check-out
19Mar2026Select date
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

4745 Transformation Way, Jacksonville, Florida, United States, FL 32224
-
Near Castaway Island Preserve
Great
8.8
/10

Accommodations

Hilton Jacksonville At Mayo Clinic offers 256 accessible and spacious guest rooms, including 48 suites. Many rooms provide views of the St. Johns River and feature conveniences such as mini-refrigerators and separate living areas. The signature Serenity Bed provides a restful sleep experience.

Dining Options

On-site dining is available at the Cafe 515, which serves breakfast, lunch, and dinner with a variety of options. The Lounge offers a casual environment for evening relaxation along with signature cocktails and small plates. There are also flexible dining options for special events and meetings.

Location Benefits

Conveniently located next to Mayo Clinic, the hotel provides easy access to medical facilities for patients and visitors. It is situated approximately 25 minutes from downtown Jacksonville and offers proximity to attractions like the Jacksonville Zoo and Gardens. Guests can enjoy scenic walking trails nearby along the river.

Business Facilities

The hotel features over 4,500 square feet of flexible meeting space, accommodating various event sizes. The Pavilion Business Center provides essential services like copying and printing for corporate guests. Complimentary shuttle service is available to nearby businesses and medical facilities.

Fitness and Recreation

The hotel includes a fitness center equipped with modern cardio machines and free weights. An outdoor pool offers a pleasant space for relaxation and exercise under the sun. Guests can also access nearby recreational activities, including golf and water sports.

Highlights

Location: next to Mayo Clinic

Rooms: 256 accessible and spacious guest rooms

Dining: Cafe 515 and Lounge on-site

Business: over 4,500 square feet of flexible meeting space

Fitness: outdoor pool and fitness center

Must-do experiences

  • Visit the Cummer Museum for stunning art and beautiful gardens.
  • Enjoy fresh seafood at Safe Harbor Seafood Market & Restaurant.
  • Explore the Riverside Arts Market on Saturday for local crafts.
  • Stroll through the historic San Marco Square for boutique shops.
  • Take a sunset cruise on the St. Johns River for breathtaking views.
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Select your room type

Hilton Jacksonville At Mayo Clinic offers a variety of rooms including double rooms, family rooms, and suites with breakfast, free cancelations, and special deals
Queen Room Two Queen Beds Water View Hearing Accessible
2 persons
345 sq. feet 
2 King Size Beds
Shower
Heating
Queen Room Two Queen Beds Water View
2 persons
345 sq. feet 
2 King Size Beds
Shower
Heating
Queen Room Two Queen Beds Hearing Access
2 persons
345 sq. feet 
2 King Size Beds
Shower
Coffee machine
Queen Room Two Queen Beds
2 persons
345 sq. feet 
2 King Size Beds
Shower
Coffee machine
Click button to see more rooms
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Facilities

Hilton Jacksonville At Mayo Clinic offers amenities for your comfortable stay and unforgettable experiences

General

  • No smoking on site
  • Wi-Fi
  • Parking
  • Safe deposit box
  • 24-hour reception
  • Express check-in/ -out
  • No pets allowed
  • Rooms/ Facilities for disabled
  • Wheelchair access
  • Security
  • Lift
  • ATM/Cash machine
  • Fireplace
  • Smoke detectors
  • Electric vehicle charging station
  • Fire extinguishers
  • Key card access

Sports & Fitness

  • Fitness centre

Services

  • Room service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Shops/Commercial services
  • Welcome drink

Dining

  • In-room breakfast
  • Restaurant
  • Bar/ Lounge area

Business

  • Business centre
  • Meeting/ Banquet facilities
  • Fax/Photocopying

Children

  • Cots
  • Children's buffet

Facilities for people with disabilities

  • Toilet for disabled
  • Bathroom for disabled

Spa & Leisure

  • Outdoor swimming pool
  • Beach umbrellas
  • Sun loungers
  • Sun terrace
  • Leisure/ TV room

Room features

  • Air conditioning
  • Heating
  • Terrace
  • Garden furniture
  • Tea and coffee facilities
  • Ironing facilities

Bathroom

  • Free toiletries
  • Sink

Media

  • Flat-screen TV
  • AM/FM alarm clock

Room decor

  • Curtains
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Hilton Jacksonville At Mayo Clinic Location

4745 Transformation Way, Jacksonville, Florida, United States, FL 32224
Map view
4745 Transformation Way, Jacksonville, Florida, United States, FL 32224
Explore Jacksonville
Explore Jacksonville's Highlights
Top Attractions
Activities
Dining
Entertainment
Windsor Parke Golf Club
25 minutes' walk
A premier golf course known for its scenic layout and challenging holes, ideal for both casual and avid golfers.
Castaway Island Preserve
Castaway Island Preserve
40 minutes' walk
A beautiful nature preserve featuring trails and waterways, perfect for birdwatching and serene outdoor walks.
Jacksonville Beach Pier
Jacksonville Beach Pier
15 minutes' drive
A historic pier offering stunning ocean views and fishing opportunities, located near shops and restaurants at the beach.
Urban Golf
10 minutes' drive
An indoor golf experience featuring simulators and a sports bar, perfect for golf enthusiasts and casual players alike.
Shipwreck Island Water Park
10 minutes' drive
A family-friendly water park filled with thrilling slides and pools, great for a fun day out with the kids.
The Capital Grille
10 minutes' drive
An upscale steakhouse featuring dry-aged steaks and an extensive wine list, perfect for a special evening out.
Ocean 60
10 minutes' drive
A local favorite for seafood with a relaxed atmosphere, known for fresh ingredients and creative dishes.
Regal Beach Boulevard 18
Regal Beach Boulevard 18
10 minutes' drive
A modern cinema showcasing the latest films, complete with comfortable seating and an inviting snack bar.
Mike McCue Park and Boat Ramp
Mike McCue Park and Boat Ramp
11 minutes' drive
A great location for fishing and boating, featuring scenic views and picnic areas for family-friendly outings.
Getting around
City Centre
Jacksonville33 min  ·  13.6 mi
Airports
Jacksonville International Airport (JAX)67 min  ·  27.5 mi
St. Augustine, FL (UST)71 min  ·  29.0 mi
Train
Jacksonville Electric Authority Southside Generating Station Wharf29 min  ·  11.8 mi
Union Station35 min  ·  14.4 mi
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Property information and rules
Check-in
from 16:00-23:59
Check-out
until 11 am
Internet
Wireless internet is available in for free.
Pets
Pets are not allowed.
Number of rooms:
252

Reviews and Ratings

Feedback about Hilton Jacksonville At Mayo Clinic from previous guests about their experience.
Review score
Based on 9 verified reviews
8.6/10
Great
82%
Recommend
Guest reviews
based on 57 reviews
8.8/10
No reviews yet on our siteUnfortunately, our guests have not yet left any reviews for this hotel, but you can read reviews from Booking.com.
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FAQs
About Hilton Jacksonville At Mayo Clinic
What are the check-in and check-out times at Hilton Jacksonville At Mayo Clinic?
Check-in is available from 16:00 and check-out is until 11:00.
How far is Hilton Jacksonville At Mayo Clinic from Jacksonville International Airport?
The hotel is 42 km from Jacksonville International Airport.
Is there any on-site dining available at Hilton Jacksonville At Mayo Clinic?
The hotel features an on-site restaurant that offers a full English/Irish or American breakfast.
What amenities are available in the rooms at Hilton Jacksonville At Mayo Clinic?
Rooms include air conditioning, a flat-screen TV, a desk, and tea/coffee making equipment.
Does Hilton Jacksonville At Mayo Clinic provide parking facilities?
Free public parking is available on-site without the need for a reservation.
What recreational facilities are featured at Hilton Jacksonville At Mayo Clinic?
Guests can enjoy an outdoor swimming pool and a fitness centre.
What nearby attractions are accessible from Hilton Jacksonville At Mayo Clinic?
Nearby attractions include Jacksonville Beach Golf Club (8 km) and Kathryn Abbey Hanna Park (17 km).
Is Wi-Fi available at Hilton Jacksonville At Mayo Clinic?
Free Wi-Fi is available throughout the hotel.
What business services does Hilton Jacksonville At Mayo Clinic offer?
The hotel offers a business centre for guest use.
How far is Hilton Jacksonville At Mayo Clinic from the nearest beach?
The hotel is approximately 15 minutes' drive from Jacksonville Beach Pier.
What is the policy for breakfast at Hilton Jacksonville At Mayo Clinic?
Breakfast is available for an additional charge of 26 USD.

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Check-in
18Mar2026Select date
Check-out
19Mar2026Select date
Rooms and Guests2 Guests, 1 Room